ישעיהו סג:י פירוש: רש״י ואבן עזרא

But they rebelled Heb. מָרוּ. They angered. Comp. (Deut. 9:7) “You were rebellious (מַמְרִים).”

ועצבו And vexed. Comp. אל תעצבו be not grieved (Gen. 45:5). And vexed His holy spirit. This is a figurative expression. Some understand by the holy spirit the angel of the Lord.¹⁷In order to remove the anthropomorphism. Comp. Targ. Jonathan וארגיזו על מימר נביאי קודשיה they acted provokingly against the words of His holy prophets. He fought against them till they left His land.